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Image Search Results
Journal: Nature Communications
Article Title: Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis
doi: 10.1038/s41467-020-18180-7
Figure Lengend Snippet: The region around an associated RA variant (rs9603616) on chromosome 13 intronic of the COG6 gene was targeted in the HEK2937T cell line, using p300 as the activator. a Fold change (qPCR) effect on FOXO1 gene expression compared to negative control. b Fold change (qPCR) effect on COG6 gene expression compared to negative control.
Article Snippet: Generation of the dCas9-p300 cell line and delivery of guides : HEK293T cells were first transduced lentivirally with the
Techniques: Variant Assay, Expressing, Negative Control